Synthesis and Evaluation of Some Sulfonamide-Substituted of 1,3,5-Triphenyl Pyrazoline Derivatives as Tyrosinase Enzyme Inhibitors

Pyrazoline is well-known as heterocycles compound that can exhibit many biological effects. In this work, we synthesized a series of sulfonamide-substituted 1,3,5-triphenyl pyrazoline compounds promising tyrosinase inhibitor agent. These prepared by multicomponent reaction corresponding aldehyde, ketone, and hydrazine using seal-vessel reactor. Pyrazolines were tested for their activity through in vitro assay. The test result found 4c, 4d, 4e possessed better inhibitory compared to the reference drug, kojic acid. Compound 4c exhibited strongest effect with an IC50 value 30.14 µM. results suggested hydroxyl methoxy substituent at para position are preferable. Furthermore, molecular docking studies match pattern assay where will provide stronger binding interaction lower free energies.